Implementation strategies and feasibility Archives - Page 2 of 3

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Implementation strategies and feasibility

Prep4TBVax

2023-2025

New TB vaccines are likely to be crucial in addressing the ongoing TB pandemic. With multiple promising vaccine candidates in the pipeline and the earliest availability of a candidate expected by 2028, it is of outmost importance that once available, the vaccine can be implemented rapidly and effectively. Limited research has looked at the delivery strategies available to provide a new TB vaccine to beneficiaries and therefore, this study assesses the acceptability and feasibility of delivery strategies for the vaccine candidates M72/AS01e and MTBVAC in Ethiopia, Nigeria, and Tajikistan.

Enhancing community engagement in tuberculosis vaccine delivery among key populations: A qualitative study

This qualitative study investigated methods to enhance community engagement in TB vaccine delivery among Men Who Have Sex with Men.

Feasibility of novel adult tuberculosis vaccination in South Africa: a cost-effectiveness and budget impact analysis

2022

M72/AS01e

We conducted expert interviews to identify plausible vaccination implementation strategies for the novel M72/AS01E vaccine candidate. The strategies were defined in terms of target population, coverage, vaccination schedule and delivery mode. We modelled these strategies to estimate long-term resource requirements and health benefits arising from vaccination over 2025–2050.

BCG and new preventive tuberculosis vaccines: Implications for healthcare workers.

2016

BCG revaccination, Hypothetical vaccines

BCG and New Preventive Tuberculosis Vaccines: Implications for Healthcare Workers

An effective vaccine is only the first step: the need to create and sustain demand for TB vaccines

2023

Understanding public willingness to receive new TB vaccines, as well as defining how to address any barriers to acceptance, will be key to ensuring that the promise of these vaccines can be fully realized. Although we can learn from previous vaccine intro ductions, it is imperative we close key research gaps specific to new TB vaccines. This will inform the development of interventions to generate and sustain high demand for TB vaccines in communities that stand to benefit the most

Lessons from a decade of adult vaccine rollout in low- and middle-income countries: A scoping review

2023

This paper synthesizes the insights and lessons learned from different vaccine introductions among adult populations in LMICs from the last decade (i.e., 2013 to 2023).

Bridging the gap: evaluating high TB burden country data needs to support the potential introduction of TB vaccines for adolescents and adults: a workshop report

2024

A workshop to asked high TB burden country experts about what epidemiological, impact, feasibility and acceptability data they anticipated they would need to guide TB vaccine introduction.

Country and target population prioritization

2023-2025

Hypothetical vaccines

Evidence-based matrixing approach to identify priority countries and target populations through an iterative process, engaging a set of diverse stakeholders

Systematic review of mathematical models exploring the epidemiological impact of future TB vaccines

2016

Hypothetical vaccines

The aim was to provide a summary of the modeling methodology used, the characteristics of future TB vaccines explored using modeling, and the comparative epidemiological impact of such novel vaccine profiles.

Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines

2022

BCG revaccination, M72/AS01e

Our study provides crucial information for implementing novel TB vaccines in specific target groups and on country specific acceptability and feasibility. Key groups for vaccine implementation in these settings were identified, and should be included in clinical trials and implementation planning.