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https://tbvaccinesforum.org/rio-de-janeiro/2024-posters/

Perceptions of the incarcerated population regarding tuberculosis research and vaccines

A qualitative study that aims to understand to perceptions and attitudes regarding TB, TB vaccines, and participation in TB vaccine trials among persons deprived of liberty (PDR) in Brazil.

Navigating the unknown: Ensuring equitable TB vaccine access to maximize health impact

2024

Ongoing

A scoping literature review is underway to identify key principles and strategies from existing vaccine allocation frameworks. The review focuses on vaccines utilized in routine and emergency contexts, including malaria, COVID-19, dengue, and meningococcal vaccines, among others.

Potential implications of reduced tuberculosis vaccine efficacy in those with undernutrition on overall vaccine impact in India

Hypothetical vaccine

Ongoing

Nutritional status is a leading risk factor for tuberculosis (TB). In India up to half of all TB episodes are attributed to undernutrition. Given the impact of nutrition on the immune system, vaccine characteristics such as efficacy and duration of protection could vary depending on nutritional status. Therefore, previous vaccine impact estimates may be overestimated. We re estimated vaccine impact in India with reduced efficacy with undernutrition

Evolution of Tuberculosis Vaccine Modelling studies: Insights from studies in India

Ongoing

Focusing on India, we performed a scoping review to identify and evaluate studies that have used mathematical modeling to assess the epidemiological and economic impact of TB vaccine introduction in India

Enhancing community engagement in tuberculosis vaccine delivery among key populations: A qualitative study

Ongoing

This qualitative study investigated methods to enhance community engagement in TB vaccine delivery among Men Who Have Sex with Men.

The implications of using different time horizons when evaluating investment to prevent infectious disease

Hypothetical vaccine

Ongoing

A lifetime time horizon is conventional for cost-effectiveness analysis, but not routine for transmission-dynamic modeling, given uncertainty in future epidemiological dynamics and high computation costs. We demonstrate implications of alternative analytic time horizons with a case study of novel tuberculosis (TB) vaccine introduction

Insights into TB vaccine acceptability among adolescents in Khayelitsha through community engagement

Ongoing

Initially designed as an internal assessment of the impact of engagement workshops, we used short surveys to understand high-school learner perspectives of vaccines, focusing on COVID 19, TB and HIV vaccines. Between 2022 and 2024, we collected responses from 350 adolescents (14-18 years old). All participants live in Khayelitsha, where high rates of TB (4224 cases notified in the last year) intersect with socio-economic challenges

New tuberculosis vaccines are in late-stage trials, but how confident is the public in high burden countries in vaccines?

Ongoing

With tuberculosis (TB) vaccine candidates in late-stage trials, it is important to prepare for implementation to avoid delays upon licensure. General confidence in vaccines has been identified as an anticipated barrier to introducing new TB vaccines. In the absence of detailed TB specific vaccine acceptability and confidence data, we analysed currently available vaccine confidence data in countries appearing on one of the World Health Organization (WHO) high burden lists to investigate vaccine confidence in countries with a high TB burden

Preparing the landscape for TB vaccines: South Africa’s strategic planning

Ongoing

The South African TB Think Tank is a national collaboration of TB stakeholders, including researchers, policymakers, clinicians, and civil society. Chaired by the Chief Director of the National TB Programme (NTP), members consolidate TB research through several technical task teams, providing evidenced-based policy recommendations to the Department of Health. To support the national TB vaccine initiative, the TB Think Tank provided recommendations for the recently released NTP Strategic Plan, 2023-28

Forecasting TB vaccine demand to support supply and procurement planning

Ongoing

We present insights from two workshops with global health funders, academics, and in country TB and vaccine decision-makers and estimates of potential global demand for TB vaccines using a bottom-up, constrained demand forecasting model. The model was informed by the workshops, publicly available target product profile, landscape assessment of vaccines in development, information from proxy vaccines sourced from the WHO databases and peer reviewed literature, and interviews with TB and vaccine experts