2024 Archives - TBC repository

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2024

Attitudes towards new tuberculosis vaccines among adults, adolescents and their caregivers in southern Mozambique

2024

We investigated willingness to be vaccinated with a new TB vaccine in a high HIV and TB burden setting in southern Mozambique in 2024 using a mixed methods approach involving a cross-sectional survey and concurrent in-depth interviews.

Prevention is better than cure’: a mixed methods study of communities’ and healthcare workers’ perspectives on new adult and adolescent TB vaccines and their implementation in Zambia

2024

Hypothetical vaccines

Mixed methods study examining community members' and healthcare workers' views on future TB vaccines for adults and adolescents in Zamibia. It assesses willingness to receive a TB vaccine, preferred vaccine characteristics, concerns about safety and efficacy, trusted information sources, barriers to uptake, and preferred approaches for vaccine delivery and implementation.

TB vaccine advocacy and acceptance in South Africa

2024

Gathering a range of perspectives to provide early-stage insights into TB vaccine advocacy and acceptance in South Africa

Navigating the unknown: Ensuring equitable TB vaccine access to maximize health impact

2024

A scoping literature review is underway to identify key principles and strategies from existing vaccine allocation frameworks. The review focuses on vaccines utilized in routine and emergency contexts, including malaria, COVID-19, dengue, and meningococcal vaccines, among others.

The full value of vaccine assessments concept—current opportunities and recommendations

2024

Building on the success of the recent applications of the FVVA framework, we see important new opportunities to maximize the future utility of FVVAs to country and global stakeholders and provide a proof-of-concept for analyses in other areas of disease control and prevention.

Bridging the gap: evaluating high TB burden country data needs to support the potential introduction of TB vaccines for adolescents and adults: a workshop report

2024

A workshop to asked high TB burden country experts about what epidemiological, impact, feasibility and acceptability data they anticipated they would need to guide TB vaccine introduction.

Estimating the potential public health value of BCG revaccination

2024

BCG revaccination

Using previously calibrated models for India and South Africa, we simulated BCG revaccination assuming 45% prevention-of-infection efficacy, and we evaluated scenarios varying additional prevention-of-disease efficacy between +50% (reducing risk) and −50% (increasing risk).

Mapping the existing body of knowledge on new and repurposed TB vaccine implementation: A scoping review

2024

BCG revaccination, Hypothetical vaccines, M72/AS01e

By synthesizing the existing body of knowledge, this review offers comprehensive insights into the current state of research on implementation of these TB adults and adolescent vaccines. Offering insights into key dimensions: (1) epidemiological impact, (2) costing, cost-effectiveness, and/or economic impact, (3) acceptability, and the (4) feasibility of implementation; this includes implementation strategies of target populations, and health system capabilities.

What do people want?

2024

Hypothetical vaccines

Investigate current TB prevention modalities vs vaccine. We lack understanding of preferences and trade offs people would be willing to make across a spectrum of issues related to study design, type of vaccines, how they are given, how often, where they are given, to whom, efficacy estimates and side effects etc.

TPTVaxx

2024

Vaccines will be introduced in contexts where TPT already exists. Exploration of possible study designs, expected effectiveness, feasibility of integrated approaches is key.