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Anticipating tuberculosis vaccine acceptability in Kenya and South Africa

2015-2026

Assesses willingness to receive a new TB vaccine and explores attitudes, vaccine confidence, hesitancy, information needs and factors influencing potential uptake among adults, adolescents and caregivers in southern Mozambique. The study used surveys and in-depth interviews and found 77% willingness to receive a new TB vaccine among adults and adolescents.

Acceptability of a proposed new tuberculosis vaccine among people deprived of liberty in Brazil

2025

Hypothetical vaccines

Assesses acceptance of a hypothetical new TB vaccine and factors associated with vaccine hesitancy among people deprived of liberty in Brazil. The study surveyed 941 people across eight prison units in six Brazilian cities. It found 95.2% reported that they would accept a new TB vaccine if available

Preparing for Tuberculosis Vaccine M72/AS01E Implementation

2026

M72/AS01e

This correction relates to the global demand forecast for the potential implementation of the M72/AS01E TB vaccine

Insights on the implementation strategies for a potential new tuberculosis vaccine in South Africa

2026

Novel TB vaccines

Examines how a potential new TB vaccine could be introduced in South Africa. Interviews with 26 stakeholders explored implementation priorities, target populations, vaccine price, cost-effectiveness, regulatory approval, financing, procurement, delivery logistics, vaccine acceptability and lessons from existing vaccination programmes.

Oral delivery of BCG Moreau Rio de Janeiro gives equivalent protection against tuberculosis but with reduced pathology compared to parenteral BCG Danish vaccination

2010

BCG Danish 1331, BCG Moreau Rio de Janeiro, recombinant BCG Moreau-RdJ-Ag85B-ESAT6

Compares orally delivered BCG Moreau Rio de Janeiro with standard subcutaneous BCG Danish vaccination in a guinea-pig model of pulmonary TB. The study found that oral BCG provided protection comparable to standard formulations.

Advanced statistical approaches in tuberculosis diagnosis and treatment outcomes in Africa

2010-2026

BCG vaccine

Examines advanced statistical and computational methods used to improve TB diagnosis and treatment outcomes in Africa. It highlights how these approaches can identify TB patterns, predict outcomes, and improve diagnostic accuracy

Asymptomatic TB

2026

The study investigates the biological characteristics of asymptomatic TB and identifies two distinct subtypes with different disease severity. It highlights the difficulty of detecting asymptomatic TB using current screening approaches and the potential for undetected individuals to contribute to TB transmission

Study finds a ‘balanced’ immune response in the lungs is key to protection from developing Tuberculosis

2026

Hypothetical vaccines

This study investigates lung immune responses in people recently exposed to TB to understand why some control the infection while others develop TB disease. It identifies a balance between inflammatory neutrophils and protective T-cell response as an important factor in controlling TB

The potential health and economic impact of introducing the vaccine candidate VPM1002 to prevent tuberculosis disease in low- and middle-income countries

2026

VPM1002

This study estimates the potential health and economic impact of introducing the TB vaccine candidate VPM1002 in 79 low- and middle- income countries. It models routine vaccination and vaccination campaigns, estimating TB cases and deaths averted and the cost-effectiveness of different introduction scenarios. It provides evidence for decisions about the potential future introduction and scale-up of VPM1002

The potential impact of novel tuberculosis vaccine introduction on economic growth in low- and middle-income countries

2023

Hypothetical vaccines

Estiamtes the potential economic impact of introducing novel TB vaccines in 105 low- and middle- income countries. It compares ifnant and adolescents/ adult vaccination scenarios and models their effects on TB- related mortality, morbidity, healthcare costs and GDP. Finding support decision making on the future development and introduciton of novel TB vaccines