Prevention of disease Archives

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Prevention of disease

Prevention of disease refers to the ability of the vaccine to protect individuals from becoming sick from the tuberculosis (TB) bacteria after exposure to it. It does not necessarily prevent a person from getting infected with the TB bacteria.

Research overview-2025: integrating scientific progress to accelerate global tuberculosis elimination

2025-2026

Hypothetical vaccines

Reviews scientific progress in tuberculosis research during 2025 and discusses how advances across different areas can contribute to accelerating global TB eliminated including progress in tuberculosis vaccine development

Tuberculosis policy should shift focus to population-level interventions for greatest impact

2026

Hypothetical vaccines

Uses mathematical modelling to compare the population-level health and economic impacts of TB interventions in Brazil, India and South Africa. It highlights mass vaccination and community-wide screening as interventions with the potential for substantial epidemiological impact.

How to introduce new TB vaccine in adolescents and adults: Insights from Key Stakeholders in Mozambique, Southern Africa

2024-2026

Hypothetical vaccines

Assesses stakeholder perspectives on introducing a new TB vaccine in Mozambique, including with high-risk groups should be prioritised, challenges in reaching different populations, expected vaccine uptake and coverage, and appropriate delivery stategies.

Target Tuberculosis vaccination strategies in the United States

2026

Hypothetical vaccines

Uses a mathematical model to evaluate targeted TB vaccination strategies in the United States. The study examines which high-risk groups should be prioritised for a future adult TB vaccine, including people living with HIV, people with medical comorbidities, and people born outside the United States

Attitudes towards new tuberculosis vaccines among adults, adolescents and their caregivers in southern Mozambique

2024

Hypothetical vaccines

We investigated willingness to be vaccinated with a new TB vaccine in a high HIV and TB burden setting in southern Mozambique in 2024 using a mixed methods approach involving a cross-sectional survey and concurrent in-depth interviews.

Advancing national preparedness for the introduction of novel tuberculosis vaccines in South Africa

2025-2026

M72/AS01e, MTBVAC

The workshop aimed to align stakeholders on priority populations and delivery strategies for future TB vaccines, identify evidence needs to inform national policy decision-making, and outline actions required to ensure timely and equitable introduction.

Anticipating tuberculosis vaccine acceptability in Kenya and South Africa

2015-2026

Hypothetical vaccines

Assesses willingness to receive a new TB vaccine and explores attitudes, vaccine confidence, hesitancy, information needs and factors influencing potential uptake among adults, adolescents and caregivers in southern Mozambique. The study used surveys and in-depth interviews and found 77% willingness to receive a new TB vaccine among adults and adolescents.

Acceptability of a proposed new tuberculosis vaccine among people deprived of liberty in Brazil

2025

Hypothetical vaccines

Assesses acceptance of a hypothetical new TB vaccine and factors associated with vaccine hesitancy among people deprived of liberty in Brazil. The study surveyed 941 people across eight prison units in six Brazilian cities. It found 95.2% reported that they would accept a new TB vaccine if available

Accelerating research and development of new vaccines against tuberculosis

2021-2025

Hypothetical vaccines

Reviews progress since the 2021 Global TB Vaccine R&D Roadmap and identifies remaining actions needed to accelerate availability, access and uptake of new TB vaccines

Preparing for Tuberculosis Vaccine M72/AS01E Implementation

2026

M72/AS01e

This correction relates to the global demand forecast for the potential implementation of the M72/AS01E TB vaccine