Prevention of disease Archives - Page 2 of 4

Home
/
Projects
/

Prevention of disease

Prevention of disease refers to the ability of the vaccine to protect individuals from becoming sick from the tuberculosis (TB) bacteria after exposure to it. It does not necessarily prevent a person from getting infected with the TB bacteria.

Cost-effectiveness of routine adolescent vaccination with an M72/AS01E-like tuberculosis vaccine in South Africa and India

2022

M72/AS01e

Completed

We estimated the impact and cost-effectiveness of six scenarios of routine adolescent M72/AS01E-like vaccination in South Africa and India.

Impact and cost-effectiveness of new tuberculosis vaccines in low- and middle-income countries.

2014

Hypothetical vaccines

Completed

To aid in prioritizing the development of tuberculosis (TB) vaccines most likely to reach the 2050 TB elimination goal, we estimated the impact and cost-effectiveness of a range of vaccine profiles in low- and middle-income countries.

Affordability of adult tuberculosis vaccination in India and China: A dynamic transmission model-based analysis

2021

M72/AS01e

Completed

To estimate the total disability adjusted life years (DALYs) averted by the vaccination programme, we simulated a 50% efficacy vaccine providing 10-years of protection in post-infection populations between 2027 and 2050 in India and China using a dynamic transmission model of M. tuberculosis.

Age-targeted tuberculosis vaccination in China and implications for vaccine development: a modelling study.

2019

Hypothetical vaccines

Completed

We modelled the potential impact of new tuberculosis vaccines in China targeting adolescents (15–19 years) or older adults (60–64 years) with varying vaccine characteristics to inform strategic vaccine development.

New tuberculosis vaccines in India: Modelling the potential health and economic impacts of adolescent/adult vaccination with M72/AS01E and BCG-revaccination

2023

BCG revaccination, M72/AS01e

Completed

We estimated the potential health and economic impact of M72/AS01E and BCG-revaccination in India and investigated the impact of variation in vaccine characteristics and delivery strategies.

BCG and new preventive tuberculosis vaccines: Implications for healthcare workers.

2016

BCG revaccination, Hypothetical vaccines

Completed

BCG and New Preventive Tuberculosis Vaccines: Implications for Healthcare Workers

Estimating the epidemiologic impact of new TB vaccines in high-burden settings

2022-2027

Hypothetical vaccines, M72/AS01e

Ongoing

This is an NIH-funded study which will estimate the health impact of introducing a prevention of disease vaccine for adult and adolescents in moderate to high TB burden countries. We are developing model scenarios based on input from country stakeholders, including national TB program and immunization program officials.

Estimating the epidemiologic impact of new TB vaccines in the U.S.

2022-2024

Hypothetical vaccines

Ongoing

This is a study funded by the American Lung Association which will explore the potential impact of targeted implementation of a prevention of disease vaccine in a low TB burden country, the U.S.A.

Formative work to understand factors affecting future TB vaccines acceptance and readiness

2023-2027

Hypothetical vaccines

Ongoing

This project aims to collect data to: 1) Assess health facility and health systems readiness for a new TB vaccine, and 2) Explore decision-making factors for new TB vaccine demand and acceptance

Demand insights for uptake of TB vaccine

2022

Hypothetical vaccines

Completed

Summarize the major swing factors that would determine countries’ preference and effectively drive the uptake of a TB vaccine in terms of the date of introduction and the scale of catch-up campaign to reach the steady state