Modelling Archives - Page 2 of 4

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Potential impact of tuberculosis vaccines in China, South Africa, and India

2020

To inform vaccine development decision making, we modeled the impact of hypothetical tuberculosis vaccines in three high-burden countries.

The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug resistant tuberculosis in India and China

2021

Hypothetical vaccines

Completed

We investigated the epidemiologic impact, cost-effectiveness, and budget impact of hypothetical novel prophylactic prevention of disease TB vaccines on RR/MDR-TB in China and India.

Potential impact of spatially targeted adult tuberculosis vaccine in Gujarat, India

2016

Hypothetical vaccines

Completed

we aimed to estimate the impact of vaccine delivery strategies that were targeted to high-incidence geographical 'hotspots' compared with randomly allocated vaccination. We developed a spatially explicit mathematical model of TB transmission that distinguished these hotspots from the general population.

The health and economic benefits possible with novel tuberculosis vaccines – A modeling study in India and Indonesia

2021

M72/AS01e

Completed

We estimated gains possible with novel post-exposure vaccines, in India and Indonesia. We modeled vaccine impact on TB incidence, TB mortality, and on national income growth and the intrinsic value of living longer, known as Full-income.

Making wider use of the world’s most widely used vaccine: Bacille Calmette-Guerin revaccination reconsidered

2013

BCG revaccination

Completed

This paper assesses the effectiveness and cost-effectiveness of revaccinating adolescents in a setting with intense transmission—Cape Town, South Africa.

New tuberculosis vaccines in India: Modelling the potential health and economic impacts of adolescent/adult vaccination with M72/AS01E and BCG-revaccination

2023

BCG revaccination, M72/AS01e

Completed

We estimated the potential health and economic impact of M72/AS01E and BCG-revaccination in India and investigated the impact of variation in vaccine characteristics and delivery strategies.

Mixed vaccination strategy for the control of tuberculosis: A case study in China

2017

Hypothetical vaccines

Completed

This study first presents a mathematical model of TB transmission considering BCG vaccination compartment to investigate the transmission dynamics nowadays

Epidemiological impact of targeted interventions for people with diabetes mellitus on tuberculosis transmission in India: Modelling based predictions

2020

Hypothetical vaccines

Completed

We aimed to assess the impact on TB disease of several intervention strategies targeting people with DM in India.

Cost-effectiveness of routine adolescent vaccination with an M72/AS01E-like tuberculosis vaccine in South Africa and India

2022

M72/AS01e

Completed

We estimated the impact and cost-effectiveness of six scenarios of routine adolescent M72/AS01E-like vaccination in South Africa and India.

Age-targeted tuberculosis vaccination in China and implications for vaccine development: a modelling study.

2019

Hypothetical vaccines

Completed

We modelled the potential impact of new tuberculosis vaccines in China targeting adolescents (15–19 years) or older adults (60–64 years) with varying vaccine characteristics to inform strategic vaccine development.