Acceptability and demand Archives

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Acceptability and demand

ZAMSA-TB: Advancing epidemiological methods for surveillance of Mycobacterium tuberculosis infection

2024-2028

Multi-country study developing and validating clinic-based convenience sampling of Mtb immunoreactivity (IGRA) in children aged 1-5 as a sentinel measure of recent TB transmission. Outputs include geospatial identification of high-transmission neighbourhoods to target adult/adolescent vaccine delivery, and Monte Carlo simulations to size convenience-sampling surveys able to detect population-level vaccine effectiveness during roll-out.

Stakeholder perspectives on the potential introduction of a novel tuberculosis vaccine for adolescents and adults in Pakistan: A qualitative study

2024-2026

Hypothetical vaccines

Tuberculosis (TB) remains a major public health challenge globally, with Pakistan ranking among the highest TB burden countries worldwide. Although several novel TB vaccine candidates for adolescents and adults are advancing through late-stage clinical trials, little is known about how these vaccines may be introduced in high-burden settings such as Pakistan. Understanding stakeholder perspectives is crucial for informing early implementation planning and policy development

Knowledge of tuberculosis and vaccine trial preparedness in Lima, Peru

2017

Hypothetical vaccines

Study asseses knowledge and perception of TB among people in Lima, Peru with particular attention to their willingness and preparedness to participate in a future TB vaccine trial. It examined factors that could influence participation, including knowledge of TB, attitudes towards vaccination, and willingness to participate in research.

How to introduce new TB vaccine in adolescents and adults: Insights from Key Stakeholders in Mozambique, Southern Africa

2024-2026

Hypothetical vaccines

Assesses stakeholder perspectives on introducing a new TB vaccine in Mozambique, including with high-risk groups should be prioritised, challenges in reaching different populations, expected vaccine uptake and coverage, and appropriate delivery stategies.

Attitudes towards new tuberculosis vaccines among adults, adolescents and their caregivers in southern Mozambique

2024

Hypothetical vaccines

We investigated willingness to be vaccinated with a new TB vaccine in a high HIV and TB burden setting in southern Mozambique in 2024 using a mixed methods approach involving a cross-sectional survey and concurrent in-depth interviews.

Anticipating tuberculosis vaccine acceptability in Kenya and South Africa

2015-2026

Hypothetical vaccines

Assesses willingness to receive a new TB vaccine and explores attitudes, vaccine confidence, hesitancy, information needs and factors influencing potential uptake among adults, adolescents and caregivers in southern Mozambique. The study used surveys and in-depth interviews and found 77% willingness to receive a new TB vaccine among adults and adolescents.

Acceptability of a proposed new tuberculosis vaccine among people deprived of liberty in Brazil

2025

Hypothetical vaccines

Assesses acceptance of a hypothetical new TB vaccine and factors associated with vaccine hesitancy among people deprived of liberty in Brazil. The study surveyed 941 people across eight prison units in six Brazilian cities. It found 95.2% reported that they would accept a new TB vaccine if available

Accelerating research and development of new vaccines against tuberculosis

2021-2025

Hypothetical vaccines

Reviews progress since the 2021 Global TB Vaccine R&D Roadmap and identifies remaining actions needed to accelerate availability, access and uptake of new TB vaccines

Willingness to receive a future adult tuberculosis vaccine in Lusaka, Zambia: Perspectives from community members and healthcare workers

One or more new adult TB vaccines could become available in the next 5-7 years. To assess willingness to receive a new TB vaccine, we conducted a household- and facility-based survey among adult community members and healthcare workers (HCWs), respectively, in Lusaka, Zambia

Acceptability of and confidence in novel tuberculosis vaccines among adults living with HIV

2026

Hypothetical vaccines

Objective: Several novel tuberculosis vaccines (NTVs) are being evaluated in clinical trials. Understanding the perception of acceptability and confidence in NTVs will inform implementation strategies. Conclusion: NTV acceptability was high amongst these PWH, and they preferred community-based delivery models. Our findings may inform strategies to increase implementation of NTVs among PWH in South Africa.