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JHU

Johns Hopkins University Center for Tuberculosis Research (jhu.edu)

Potential impact of spatially targeted adult tuberculosis vaccine in Gujarat, India

2016

we aimed to estimate the impact of vaccine delivery strategies that were targeted to high-incidence geographical 'hotspots' compared with randomly allocated vaccination. We developed a spatially explicit mathematical model of TB transmission that distinguished these hotspots from the general population.

Formative work to understand factors affecting future TB vaccines acceptance and readiness

2023-2027

Hypothetical vaccines

Ongoing

This project aims to collect data to: 1) Assess health facility and health systems readiness for a new TB vaccine, and 2) Explore decision-making factors for new TB vaccine demand and acceptance

Foster political, advocacy for TB vaccines R&D, and enhanced community engagement

2023

Planned

Innovative Financing for TB vaccine R&D

2023

Ongoing

T20 policy brief

Lessons from a decade of adult vaccine rollout in low- and middle-income countries: A scoping review

2023

Ongoing

This paper synthesizes the insights and lessons learned from different vaccine introductions among adult populations in LMICs from the last decade (i.e., 2013 to 2023).

Bridging the gap: evaluating high TB burden country data needs to support the potential introduction of TB vaccines for adolescents and adults: a workshop report

2024

Completed

A workshop to asked high TB burden country experts about what epidemiological, impact, feasibility and acceptability data they anticipated they would need to guide TB vaccine introduction.

Country and target population prioritization

2023-2024

Hypothetical vaccines

Ongoing

Evidence-based matrixing approach to identify priority countries and target populations through an iterative process, engaging a set of diverse stakeholders

Mapping the existing body of knowledge on new and repurposed TB vaccine implementation: A scoping review

2024

BCG revaccination, Hypothetical vaccines, M72/AS01e

Completed

By synthesizing the existing body of knowledge, this review offers comprehensive insights into the current state of research on implementation of these TB adults and adolescent vaccines. Offering insights into key dimensions: (1) epidemiological impact, (2) costing, cost-effectiveness, and/or economic impact, (3) acceptability, and the (4) feasibility of implementation; this includes implementation strategies of target populations, and health system capabilities.