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Johns Hopkins University Center for Tuberculosis Research (jhu.edu)

Estimating the population impact of new tuberculosis vaccines depending on efficacy against infectious asymptomatic tuberculosis:

2026

Uses a dynamic TB transmission model to estimate how the population impact of future TB vaccines changes depending on whether vaccines prevent progression to infectious symptomatic TB only, all infectious TB, or all TB disease.

Includion of young adolescents in policy development for new tuberculosis vaccines

2026

M72/AS01e, MTBVAC

Reviews the inclusion of young adolescents aged 9-14 years in policy development for new TB vaccines, including the potential benefits of adolescent vaccination, evidence requirements, trial design, implementation considerations, and integration with existing adolescent vaccination programmes

Willingness to receive a future adult tuberculosis vaccine in Lusaka, Zambia: Perspectives from community members and healthcare workers

One or more new adult TB vaccines could become available in the next 5-7 years. To assess willingness to receive a new TB vaccine, we conducted a household- and facility-based survey among adult community members and healthcare workers (HCWs), respectively, in Lusaka, Zambia

A model for the epidemiological impact of tuberculosis policy options

2026

Hypothetical vaccines

Develops a new TB transmission model to help decision-makers comapre the epidemiological impact of different TB interventions and allocate resources. The model incorporates diagnosis, treatment, drug resistance, HIV status, age, and vaccination status, and was calibrated using data from 29 high burden countries. It demonstrates the potential impact of comprehensive TB interventions in Indonesia and Nigeria, including the possible use of a post-exposure TB vaccine

Prevention is better than cure’: a mixed methods study of communities’ and healthcare workers’ perspectives on new adult and adolescent TB vaccines and their implementation in Zambia

2024

Hypothetical vaccines

Mixed methods study examining community members' and healthcare workers' views on future TB vaccines for adults and adolescents in Zamibia. It assesses willingness to receive a TB vaccine, preferred vaccine characteristics, concerns about safety and efficacy, trusted information sources, barriers to uptake, and preferred approaches for vaccine delivery and implementation.

Willingness to receive a future TB vaccine among pregnant women living in Brazil, Ghana, Kenya, and Pakistan

Our study assessed the willingness of pregnant women across four countries - Brazil, Ghana, Kenya, and Pakistan to receive a future TB vaccine.

Navigating the unknown: Ensuring equitable TB vaccine access to maximize health impact

2024

A scoping literature review is underway to identify key principles and strategies from existing vaccine allocation frameworks. The review focuses on vaccines utilized in routine and emergency contexts, including malaria, COVID-19, dengue, and meningococcal vaccines, among others.

Financing and policy innovation to advance TB vaccines through licensure: A G20 policy proposal

The authors developed two T20 policy briefs proposing recommendations to enhance G20 leadership and bring TB vaccines through licensure: Investment Toolbox to Advance TB Vaccine R&D through Joint Action (2023); and Elevating Leadership of HBC G20 States in TB Vaccine R&D and Delivery (2024). The briefs were informed by extensive literature research and aligned with global initiatives for TB and TB vaccine R&D.

Potential impact of spatially targeted adult tuberculosis vaccine in Gujarat, India

2016

Hypothetical vaccines

we aimed to estimate the impact of vaccine delivery strategies that were targeted to high-incidence geographical 'hotspots' compared with randomly allocated vaccination. We developed a spatially explicit mathematical model of TB transmission that distinguished these hotspots from the general population.

Innovative Financing for TB vaccine R&D

2023

T20 policy brief