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How to introduce new TB vaccine in adolescents and adults: Insights from Key Stakeholders in Mozambique, Southern Africa

2024-2026

Assesses stakeholder perspectives on introducing a new TB vaccine in Mozambique, including with high-risk groups should be prioritised, challenges in reaching different populations, expected vaccine uptake and coverage, and appropriate delivery stategies.

Attitudes towards new tuberculosis vaccines among adults, adolescents and their caregivers in southern Mozambique

2024

Hypothetical vaccines

We investigated willingness to be vaccinated with a new TB vaccine in a high HIV and TB burden setting in southern Mozambique in 2024 using a mixed methods approach involving a cross-sectional survey and concurrent in-depth interviews.

Anticipating tuberculosis vaccine acceptability in Kenya and South Africa

2015-2026

Hypothetical vaccines

Assesses willingness to receive a new TB vaccine and explores attitudes, vaccine confidence, hesitancy, information needs and factors influencing potential uptake among adults, adolescents and caregivers in southern Mozambique. The study used surveys and in-depth interviews and found 77% willingness to receive a new TB vaccine among adults and adolescents.

Advancing national preparedness for the introduction of novel tuberculosis vaccines in South Africa

2025-2026

M72/AS01e, MTBVAC

The workshop aimed to align stakeholders on priority populations and delivery strategies for future TB vaccines, identify evidence needs to inform national policy decision-making, and outline actions required to ensure timely and equitable introduction.

Accelerating research and development of new vaccines against tuberculosis

2021-2025

Hypothetical vaccines

Reviews progress since the 2021 Global TB Vaccine R&D Roadmap and identifies remaining actions needed to accelerate availability, access and uptake of new TB vaccines

Preparing for Tuberculosis Vaccine M72/AS01E Implementation

2026

M72/AS01e

This correction relates to the global demand forecast for the potential implementation of the M72/AS01E TB vaccine

Insights on the implementation strategies for a potential new tuberculosis vaccine in South Africa

2026

Hypothetical vaccines

Examines how a potential new TB vaccine could be introduced in South Africa. Interviews with 26 stakeholders explored implementation priorities, target populations, vaccine price, cost-effectiveness, regulatory approval, financing, procurement, delivery logistics, vaccine acceptability and lessons from existing vaccination programmes.

Tuberculosis policy should shift focus to population-level interventions for greatest impact

2026

Hypothetical vaccines

Uses mathematical modelling to compare the population-level health and economic impacts of TB interventions in Brazil, India and South Africa. It highlights mass vaccination and community-wide screening as interventions with the potential for substantial epidemiological impact.

ZAMSA-TB: Advancing epidemiological methods for surveillance of Mycobacterium tuberculosis infection

2024-2028

Hypothetical vaccines, M72/AS01e

Multi-country study developing and validating clinic-based convenience sampling of Mtb immunoreactivity (IGRA) in children aged 1-5 as a sentinel measure of recent TB transmission. Outputs include geospatial identification of high-transmission neighbourhoods to target adult/adolescent vaccine delivery, and Monte Carlo simulations to size convenience-sampling surveys able to detect population-level vaccine effectiveness during roll-out.

Stakeholder perspectives on the potential introduction of a novel tuberculosis vaccine for adolescents and adults in Pakistan: A qualitative study

2024-2026

Hypothetical vaccines

Tuberculosis (TB) remains a major public health challenge globally, with Pakistan ranking among the highest TB burden countries worldwide. Although several novel TB vaccine candidates for adolescents and adults are advancing through late-stage clinical trials, little is known about how these vaccines may be introduced in high-burden settings such as Pakistan. Understanding stakeholder perspectives is crucial for informing early implementation planning and policy development