research Archives - Page 4 of 5

Hypothetical vaccines, M72/AS01e

From 2023 onwards we modelled a combination of interventions acting at different stages of the care cascade, including improved diagnostics; reducing the patient care seeking delay; and the rollout of a disease-preventing vaccine from 2025 onwards.

Estimating the epidemiologic impact of new TB vaccines in high-burden settings

2022-2027

Ongoing

This is an NIH-funded study which will estimate the health impact of introducing a prevention of disease vaccine for adult and adolescents in moderate to high TB burden countries. We are developing model scenarios based on input from country stakeholders, including national TB program and immunization program officials.

The impact of alternative delivery strategies for novel tuberculosis vaccines in low-income and middle-income countries: a modelling study

We estimated the impact of novel tuberculosis vaccines in low-income and middle-income countries (LMICs) in several delivery scenarios.

The cost and cost-effectiveness of novel tuberculosis vaccines in low- and middle-income countries: A modeling study

We assessed future costs, cost-savings, and cost-effectiveness of introducing novel TB vaccines in low- and middle-income countries (LMICs) for a range of product characteristics and delivery strategies.

The potential impact of novel tuberculosis vaccines on health equity and financial protection in low-income and middle-income countries

We assessed the potential financial risk protection from introducing novel TB vaccines, and how health and economic benefits would be distributed across income quintiles.

Systematic review of mathematical models exploring the epidemiological impact of future TB vaccines

2016

The aim was to provide a summary of the modeling methodology used, the characteristics of future TB vaccines explored using modeling, and the comparative epidemiological impact of such novel vaccine profiles.

New tuberculosis vaccines: advances in clinical development and modelling

2020

BCG revaccination, M72/AS01e

We summarize the mathematical modelling literature used to inform vaccine development, focusing on models that address the epidemiologic impact of new TB vaccines. Finally,we describe the future for TB vaccines in the effort towards TB elimination

Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines

2022

Our study provides crucial information for implementing novel TB vaccines in specific target groups and on country specific acceptability and feasibility. Key groups for vaccine implementation in these settings were identified, and should be included in clinical trials and implementation planning.

Acceptability and effect on public and cost-effectiveness impact