Prevention of infection refers to the ability of the vaccine to protect individuals from becoming infected with the tuberculosis (TB) bacteria. A person cannot get TB disease if this person does not get infected. A person who is already infected with the TB bacteria prior to vaccination, may still develop TB disease in this case.
New tuberculosis vaccines: advances in clinical development and modelling
We summarize the mathematical modelling literature used to inform vaccine development, focusing on models that address the epidemiologic impact of new TB vaccines. Finally,we describe the future for TB vaccines in the effort towards TB elimination