A hypothetical TB vaccine refers to a vaccine that currently does not exist. It is a hypothetical scenario with a vaccine that may protect against infection and/or disease and/or recurrence to a certain extent. Usually WHO guidance is followed to inform these hypothetical vaccines (An investment case for new tuberculosis vaccines (who.int).
New tuberculosis vaccines: advances in clinical development and modelling
We summarize the mathematical modelling literature used to inform vaccine development, focusing on models that address the epidemiologic impact of new TB vaccines. Finally,we describe the future for TB vaccines in the effort towards TB elimination