Infants Archives - TBC repository

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Optimising DTwP-containing vaccine infant immunisation schedules in Uganda and Nepal (OptImms)

2021-2025

Evaluates alternative infant immunisation schedules in Uganda and Nepal to determine whether reduced-dose or delayed schedules can maintain adequate protection while creating space in routine immunisation programmes for the introduction of new vaccines.

Imprecision in tuberculosis infection outcomes

2025-2026

Novel TB vaccines

Assesses how imperfect sensitivity and specificity of TB infection tests can affect the results of non-inferiority TB vaccine trials. It uses statistical simulations to show that inaccurate infection markers can lead to a high risk of incorrectly declaring a new TB vaccine non-inferior

The potential impact of novel tuberculosis vaccine introduction on economic growth in low- and middle-income countries

2023

Hypothetical vaccines

Estiamtes the potential economic impact of introducing novel TB vaccines in 105 low- and middle- income countries. It compares ifnant and adolescents/ adult vaccination scenarios and models their effects on TB- related mortality, morbidity, healthcare costs and GDP. Finding support decision making on the future development and introduciton of novel TB vaccines

Non-Specific Effects of Bacillus Calmette-Guérin

2023

BCG vaccine

Systamtic review and meta-alysis evaluates whether BCG vaccination has non-specific effects beyond protection against tuebrculosis. It analyses 16 randomized controlled trials involving 34,197 participants and examines outcomes including mortality, infections and hospitalisation.

Systematic review of mathematical models exploring the epidemiological impact of future TB vaccines

2016

Hypothetical vaccines

The aim was to provide a summary of the modeling methodology used, the characteristics of future TB vaccines explored using modeling, and the comparative epidemiological impact of such novel vaccine profiles.